Progesteronreceptor

Progesteronreceptor (PR), även känd som NR3C3 (kärnreceptorunderfamilj 3, grupp C, medlem 3), är en typ av nukleär receptor som aktiveras genom att binda till progesteron i cytoplasman och translokerar sedan in i cellkärnan.

Hos människor kodas PR av en enda PGR-gen som finns på kromosom 11q22,^[1]^[2] den har två isoformer, PR-A och PR-B, som skiljer sig åt i sin molekylvikt.^[3]^[4] PR-B är den positiva regulatorn av effekterna av progesteron, medan PR-A tjänar till att motverka effekterna av PR-B.^[5]

Referenser[redigera | redigera wikitext]

^ Misrahi, Micheline; Atger, Michel; d'Auriol, Luc; Loosfelt, Hugues; Meriel, Cécile; Fridlansky, Françoise (1987-03-13). ”Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA” (på engelska). Biochemical and Biophysical Research Communications 143 (2): sid. 740–748. doi:10.1016/0006-291X(87)91416-1. ISSN 0006-291X. https://www.sciencedirect.com/science/article/pii/0006291X87914161. Läst 12 november 2021.
^ Law, M L; Kao, F T; Wei, Q; Hartz, J A; Greene, G L; Zarucki-Schulz, T (1987-05). ”The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2.”. Proceedings of the National Academy of Sciences of the United States of America 84 (9): sid. 2877–2881. ISSN 0027-8424. PMID 3472240. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC304763/. Läst 12 november 2021.
^ Gadkar-Sable, Sushama; Shah, Chirag; Rosario, Gracy; Sachdeva, Geetanjali; Puri, Chander (2005-09-01). ”Progesterone receptors: various forms and functions in reproductive tissues”. Frontiers in Bioscience: A Journal and Virtual Library 10: sid. 2118–2130. doi:10.2741/1685. ISSN 1093-9946. PMID 15970482. https://pubmed.ncbi.nlm.nih.gov/15970482/. Läst 12 november 2021.
^ ”Progesterone receptors: various forms and functions in reproductive tissues”. fbscience.com. 1 september 2005. doi:10.2741/1685. https://fbscience.com/Landmark/articles/10.2741/1685. Läst 12 november 2021.
^ Falcone, Tommaso (2013-05-22) (på engelska). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. ISBN 978-1-4614-6837-0. https://books.google.com/books?id=TAYnR1b8jRkC&pg=PA39. Läst 12 november 2021

[1] Misrahi, Micheline; Atger, Michel; d'Auriol, Luc; Loosfelt, Hugues; Meriel, Cécile; Fridlansky, Françoise (1987-03-13). ”Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA” (på engelska). Biochemical and Biophysical Research Communications 143 (2): sid. 740–748. doi:10.1016/0006-291X(87)91416-1. ISSN 0006-291X. https://www.sciencedirect.com/science/article/pii/0006291X87914161. Läst 12 november 2021.

[2] Law, M L; Kao, F T; Wei, Q; Hartz, J A; Greene, G L; Zarucki-Schulz, T (1987-05). ”The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2.”. Proceedings of the National Academy of Sciences of the United States of America 84 (9): sid. 2877–2881. ISSN 0027-8424. PMID 3472240. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC304763/. Läst 12 november 2021.

[3] Gadkar-Sable, Sushama; Shah, Chirag; Rosario, Gracy; Sachdeva, Geetanjali; Puri, Chander (2005-09-01). ”Progesterone receptors: various forms and functions in reproductive tissues”. Frontiers in Bioscience: A Journal and Virtual Library 10: sid. 2118–2130. doi:10.2741/1685. ISSN 1093-9946. PMID 15970482. https://pubmed.ncbi.nlm.nih.gov/15970482/. Läst 12 november 2021.

[4] ”Progesterone receptors: various forms and functions in reproductive tissues”. fbscience.com. 1 september 2005. doi:10.2741/1685. https://fbscience.com/Landmark/articles/10.2741/1685. Läst 12 november 2021.

[5] Falcone, Tommaso (2013-05-22) (på engelska). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. ISBN 978-1-4614-6837-0. https://books.google.com/books?id=TAYnR1b8jRkC&pg=PA39. Läst 12 november 2021

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